In the distant past, a Neanderthal family (Jorge Vargas, Tanaya Beatty), displaced from their home, struggles to survive – protecting their children and learning to wield primitive tools in an unforgiving world. In the present day, Claire (Rashida Jones), a driven post-graduate anthropologist studying ancient proto-human remains, begins a tentative relationship with a fellow student, Greg (Daveed Diggs). And two centuries later, aboard a spaceship bound for a distant planet, Coakley (Kate McKinnon) and a sentient onboard computer confront a mysterious disease threatening the ship’s oxygen-producing plants.

Three storylines, spanning thousands of years, intersect and reflect on hope, connection, and the circle of life.